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Search Results for " x receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T3550 X-376 Ensartinib,X-396 c-Met/HGFR , ALK
X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inh...
T22324 Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride Others , Trk receptor , c-Met/HGFR , ALK
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both...
T8491 Vorolanib CM082,X-82 VEGFR , PDGFR
Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.
T41255 Specific PXR antagonist 70 Others
Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.
T5178 AZ876 Liver X Receptor
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T1801 SR9243 Liver X Receptor
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
T16930 SR9238 Liver X Receptor
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
T15427 GSK2033 Liver X Receptor
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T9203 JH-X-119-01 IRAK
JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.
T7529 Yamogenin Others
Yamogenin is a diastereomer of diosgenin, which we have identified as the compound responsible for the anti-hyperlipidemic effect of fenugreek.
T2768 Saikosaponin A NF-κB , Antibacterial , Liver X Receptor
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropath...
T3955 AR7 Retinoid Receptor
AR7 is a retinoic acid receptor α (RARα) antagonist.
T27478 GSK3987 Liver X Receptor
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
T2810 (20S)-Protopanaxatriol 20(S)-APPT,g-PPT Apoptosis , Estrogen Receptor/ERR , Glucocorticoid Receptor , Estrogen/progestogen Receptor , Liver X Receptor
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid receptor.
T7768 RGX-104 RGX-104 free Acid Liver X Receptor
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
T1783 LXR-623 LXR623,WAY 252623 Liver X Receptor
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
T6310 GW3965 hydrochloride GW3965 HCl Liver X Receptor
GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
T8944 TTA-A2 Calcium Channel
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...
TQ0274 27-Hydroxycholesterol 25(R)-27-hydroxy Cholesterol Estrogen/progestogen Receptor , Liver X Receptor
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
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